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    iMatrix 411

    Induction of vascular endothelial cells from human PSCs

    Product Basics

    iMatrix-411 is a recombinant Laminin-411 E8 fragment protein used as a cell culture matrix. Laminin-411 is a predominant isoform found in the basal membrane of the endothelial cells in capillary vessels, and it mainly binds to the cell surface transmembrane receptors integrin α6β1 and α71β1.¹ The E8 fragment maintains full binding activity toward integrin, yet lacks binding activities to other components. The process of switching defined matrices is a critical tool for steering cells towards their intended fate.² Studies have demonstrated that switching the extracellular matrix (ECM) from laminin-511 E8 fragment (iMatrix-511) to laminin-411 E8 during differentiation efficiently induces endothelial progenitor cells from iPS cells. 

    ¹ Nishiuchi, R. et al. Matrix Biol. 25, 189-197-,2006
    ² Ohta R et al., Scientific Reports, 6(35680), 1-12, 2016

    Key Features

    Technical Information

    Phenotypes of endothelial cells induced from pluripotent stem cells on iMatrix-411 coated plate

    Phenotypes of endothelial cells


    • Format: Liquid Solution (175 ug/vial @0.5 mg/mL), Solvent: PBS (-)
    • Storage temperature: 2-15 °C
    • Manufactured by: Nippi, Inc. 1-1-1 Senju-Midoricho, Adachi-ku, Tokyo, Japan



    • SKU: N-892043
    • Price: $80.00
    • Incl. US (Continental) shipping fee
    • * Only one purchase per lab *
    350ug (175ug x 2 tubes)
    • SKU: N-892041
    • Price: $425.00
    1050ug (175ug x 6 tubes)
    • SKU: N-892042
    • Price: $1,100.00

    References & Literature

    Takayama K. et al., Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells. Biochemical and biophysical research communications, 474 (1), 91-96, 2016

    Ohta R et al., Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells. Scientific Reports, 6 (35680), 1-12, 2016