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    3D cell culture model for Brain

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    Biomimesys Brain Logo

    Product Basics

    BIOMIMESYS® Brain is a Hyaluronic acid (HA) based scaffold 3D cell culture model. This groundbreaking 3D cell culture technology associates the behavior of a solid scaffold and of a hydrogel, which we call “Hydroscaffold”. The Hydroscaffold’s composition and mechanical properties can mimics the microenvironment of brain tissues. It is proven to provide better in vitro/in vivo correlation than 2D models.

    Key Features

    • Mimics the microenvironment of brain tissue
    • Better in vitro/in vivo correlation
    • Ready to use
    • Applicable for most downstream applications
    • Batch to Batch consistent

    Technical Information

    Mimics the Microenvironment of Brain Tissue

    By mimicking the low stiffness of brain tissues, BIOMIMESYS® Brain allows to grow mini-brains (spheroids of brain cells) or neuronal networks in 3D.

    BIOMIMESYS® Microenvironment of Brain Tissue

    For a better in vitro/in vivo correlation

    BIOMIMESYS® Vitro/in Vivo Correlation

    By using a brain-specific ECM with BIOMIMESYS® Brain, Luhmes cells showed lower sensitivity to Parkinson’s disease inducers in BIOMIMESYS® compared to 2D culture.

    Ready to Use

    BIOMIMESYS® Oncology is EASY & READY TO USE. Upon receiving the vacuum sealed 96-well plate open it (under a hood) and add the cells directly on top of the matrix. Changing the culture medium is easy as well. To remove medium, simply draw the medium with a pipette between the matrix and the edge of the well. To refresh the medium, place fresh medium onto the surface of the matrix.

    BIOMIMESYS® Ready to Use

    Successfully Tested Cells

    Cell Lines
    Human brain metastasis: SA87
    Human neuroblastoma : SH-SY5Y
    Human glioblastoma : CB109 / CB74 / CB191
    Human gliome : DIPG007
    Normal human neurons :  Luhmes
    Normal human colon fibroblast : CCD18-co
    Normal mouse preadipocytes : 3T3-L1 / 3T3-F442A
    Human colorectal adenocarcinoma : HCT 116
    Human liver hepatocellular carcinoma

    Primary Cells
    Human astrocytes : cryopreserved
    Mouse neuronal cells

    Stem Cells
    Human induced pluripotent stem cells : CNS4U, Peri4U
    Complete List of Tested Cells [PDF]

    Compatible with Most Downstream Applications

    BIOMIMESYS® hydroscaffold has many properties (transparent, porous, biodegradable, & solid) making it ideal for use with numerous downstream applications.

    BIOMIMESYS® Analyze



    • Hyaluronic acid (HA) (1.6MDa) grafted with RGDS
    • Adipic acid dihydrazide (ADH) as crosslinker
    • Collagen Type IV
    • cationic bioplolymer

    Physicochemical Features:

    • Young’s modulus: ~0.1kPa – different stiffness is available through customization
    • Porosity: 150±30μ




    • 3D cell culture model for Brain

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    24 Hydrogel / 96 Well

    Transparent Plate
    • SKU: BIO_BRA_96_24_transp
    • Price: $300.00 → $255.00
    Black Plate
    • SKU: BIO_BRA_96_24_black
    • Price: $350.00 → $297.00

    96 Hydrogel / 96 Well

    Transparent Plate
    • SKU: BIO_BRA_96_96_transp
    • Price: $520.00 → $442.00
    Black Plate
    • SKU: BIO_BRA_96_96_black
    • Price: $570.00 → $484.00

    References & Literature

    De Conto, V. et al. In vitro differentiation modifies the neurotoxic response of SH-SY5Y cells. Toxicology in Vitro 77, 105235 (2021) doi: 10.1016/j.tiv.2021.105235.

    Other Documents