PeptiGrowth PG-007
VEGF Alternative Peptide (VEGFR2 agonist)
Product Basics
Vascular endothelial growth factor (VEGF) has the ability to promote the proliferation of endothelial cells, and it is also a key differentiation factor for endothelial cells as well as hematopoietic stem cells.
PG-007 serves as an alternative to VEGF and has been confirmed to possess phosphorylation capability on VEGFR2, demonstrating confirmed agonist activity towards VEGFR2. It also shows proliferative activity on iPSC-derived endothelial cells and supports the differentiation of iPSCs into endothelial cells. It exhibits comparable activity at 1/8 of the concentration of recombinant VGEF due to a difference in molecular weight.
Key Features
- Alternative to Vascular Endothelial Growth Factor (VEGF)
- Confirmed agonist activity towards VEGFR2
- Proliferative activity on iPSC-derived endothelial cells
- Comparable activity at 1/8 of the concentration of rVGEF*
- Stable. >80% remained after 14 days in serum free media at 37˚C
- Fully synthetic and animal-free
GMP grade can be manufactured upon request.
*Please note that this figure is an example and concentration optimization is needed.
Technical Information
(1) Confirmed agonist activity towards VEGFR2 and proliferative activity on iPSC-derived endothelial cells.
(2) iPSC derived Hematopoietic Stem Progenitor Cells (HSPCs) and NKT Cells
Differentiation efficiency of human iPSCs into endothelial cells (ECs) was evaluated when using recombinant VEGF or PG-007 (prototype)
Differentiation of iPSCs into NKT cell through hematopoietic stem and progenitor cells (HSPCs), using PeptiGrowth peptides (PG-007, 008 and 010) or using VEGF, CHIR99021 (Wnt3a agonist), and TPO.
Using PeptiGrowth peptides (PG-007, PG-008, and PG-010) reduced the culture period by one day and resulted in more than twofold increase in HSPC yield.
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Specification
- Storage temperature: -20°C (Ship at 4°C)
- Shelf life: 2 years (To be extended)
- Manufactured by: PeptiGrowth Inc.
Pricing
5ug
- SKU: PG-007-5ug
- Size: 5ug (eq. ~40ug of rVEGF)
- Price: $380.00
50ug
- SKU: PG-007-50ug
- Size: 50ug (eq. ~400ug of rVEGF)
- Price: $1,750.00
500ug
- SKU: PG-007-500ug
- Size: 500ug (eq. ~4mg of rVEGF)
- Price: $12,000.00
References
- Goolcharran, C., Jones, A. J. S. & Borchardt, R. T. Comparison of the rates of deamidation, diketopiperazine formation, and oxidation in recombinant human vascular endothelial growth factor and model peptides. AAPS PharmSci 2, 5 (2000) doi: 10.1208/ps020105.
- Shibuya, M. Vascular Endothelial Growth Factor (VEGF)-Receptor2: Its Biological Functions, Major Signaling Pathway, and Specific Ligand VEGF-E. Endothelium 13, 63–69 (2006) doi: 10.1080/10623320600697955.
- Shibuya, M. VEGFR and Type-V RTK Activation and Signaling. Cold Spring Harb Perspect Biol. 5, a009092 (2013) doi: 10.1101/cshperspect.a009092.
- Ribatti, D. The discovery of the fundamental role of VEGF in the development of the vascular system. Mechanisms of Development 160, 103579 (2019) doi: 10.1016/j.mod.2019.103579.
- A growing market for synthetically produced peptides. Nature (2022).
https://www.nature.com/articles/d42473-022-00352-2
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES