PeptiGrowth PG-005 & 006
BMP7 & BMP4 Selective Inhibitor Peptide
Product Basics
PG-005 is a synthetic peptide that selectively inhibits the BMP7 family of proteins.
PG-006 is a synthetic peptide that selectively inhibits the BMP4 family of proteins.
PG-005 and PG-006 make it possible to separately inhibit the BMP4/7 families, which was impossible with existing small kinase inhibitors or Noggin. PG-005 and PG-006 can be utilized for detailed analysis and control of BMP signaling, as well as for constructing new cellular differentiation pathways. In comparison, PG-004 inhibits both BMP4 and BMP7 families simultaneously.
PG-004 inhibits both the BMP4 and BMP7 families.
Key Features
- Enabled selective inhibition of BMP4 and BMP7 signaling
- Stable. >80%(PG-006), >90%(PG-005) remained after 14 days in serum-free media at 37˚C
- Fully synthetic and animal-free
Technical Information
Inhibitory activity against BMP4 and BMP7
PG-005(BMP4) & PG-006(BMP7)
PG-005 demonstrates selective inhibitory activity against the BMP7 family, whereas PG-006 exhibits selective inhibitory activity against the BMP4 family. Each inhibitory activity is equivalent to that of Noggin at a molar concentration. Therefore, both PG-005 and PG-006 display the same level of inhibitory activity at a lower mass concentration (ng/mL) of Noggin.
The same test with PG-005 and PG-006 only inhibits BMP4 or BMP7. Both PG-005 and PG-006 display the same level of inhibitory activity at a lower mass concentration (ng/mL) of Noggin.
PG-004 (Noggin-like Peptide)
PeptiGrowth Inc. conducted a functional comparison test between their Noggin-like Peptide (PG-004) and commercially available recombinant Noggin by measuring Smad1 phosphorylation. The results revealed that PG-004 exhibited inhibitory activity against BMP4 and BMP7 at the same level per molecule as recombinant Noggin. Furthermore, they confirmed that PG-004 also demonstrates inhibitory activity against BMP family proteins with high sequence homology to BMP4 and BMP7.
Specification
- Storage temperature: -20°C (Ship at 4°C)
- Shelf life: 2 years (To be extended)
- Manufactured by: PeptiGrowth Inc.
Pricing
Click here for PG-004
PeptiGrowth PG-005
- BMP-7 selective inhibitor
*Sample not available. Please inquire about product purchase availability.
10ug
- SKU: PG-005-10ug
- Size: 10ug
- Price: $380.00
500ug
- SKU: PG-005-500ug
- Size: 500ug
- Price: $8,400.00
PeptiGrowth PG-006
- BMP-4 selective inhibitor
*Sample not available. Please inquire about product purchase availability.
10ug
- SKU: PG-006-10ug
- Size: 10ug
- Price: $380.00
500ug
- SKU: PG-006-500ug
- Size: 500ug
- Price: $8,400.00
References
A growing market for synthetically produced peptides. Nature (2022).
https://www.nature.com/articles/d42473-022-00352-2
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES